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Imran Khan Pathan ¹, K. Narendra Babu ¹, K. K. Ashok Kumar ¹, K. Ishwarya ¹, J. Hima Kiran ¹

Affiliations
1 Department of Pharmacology, The Erode College of Pharmacy, Erode-638112, Tamilnadu, IN

Abstract

The etiology of gastrodeodenal ulcers is influenced by various aggressive and defensive factors such as acid pepsin secretion, parietal cells, mucosal barrier, mucous secretion, blood flow, cellular regeneration, endogenous productive agents (PGS and epidermic growth factors), and Helicobacter pylori (H. pylori). However, it has been suggested that free radicals are closely related with peptic ulcer and gastritis. Oxygen free radicals are detrimental to the integrity of biological tissues and mediate their injury. The mechanism of damage involves lipidperoxidation, which destroys cell membranes with the release of intracellular components, such lysosomal enzymes, leading to further tissue damage. The radicals also promote mucosal damage by causing degradation of the epithelial basement membrane components, complete alteration of the cell metabolism and DNA damage. Therefore, by scavenging free radicals, the reactive oxygen metabolites might be useful by protecting the gastric mucosa from oxidative damage or by accelerating healing of gastric ulcer. Antioxidants act as scavengers inhibit lipidperoxidation and other free radicals mediated process, and therefore they protect the human body from several diseases attributed to the reactions of radicals. In this study, the gastroprotective effect of orally administrable newly synthesized chalcone derivatives on gastric lesions by pylorus ligation induced gastric ulcer in rats and In vitro free radical scavenging activity were studied.

Keywords

Gastrodeodenal Ulcers, Helicobacter pylori, Oxygen Free Radicles, Antioxidants, Chalcone.

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A. Susmitha ¹, K. Narendra Babu ¹, Imran Khan Pathan ¹, K. Ishwarya ¹

Affiliations
1 Department of Pharmaceutics, Arulmigu Kalasalingam College of Pharmacy, Tamilnadu, IN

Abstract

The present investigation was to develop immediate release (IR) tablet formulations of Capecitabine an anti-cancer drug, using Hydroxy Propyl Methyl Cellulose (HPMC E5) as binding agent. The tablets were prepared by wet granulation process and evaluated for various physico-chemical/mechanical parameters. Among the formulations the optimised formulation was identified by comparing dissolution profiles with innovator. The formulation containing 97.5mg MCC (Avicel PH 101) as filler and 20mg HPMC E5 as binder gave a bioequivalent dissolution profile as innovator over a period of 60min (100.8 %). The dissolution data of optimized formulation was also evaluated for drug release kinetics and mechanisms. The significant factor for optimised formulation and innovator was evaluated.

Keywords

Immediate Release (IR) Tablets, Capecitabine (API), HPMC, MCC And Significant Factor.

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K. Narendra Babu ¹, Imran Khan Pathan ²

Affiliations
1 Department of Pharmaceutics, Krishna Teja Pharmacy College, Renigunta Road- 517520 Tirupati, Andhra Pradesh, IN
2 Department of Pharmaceutics, Krishna Teja Pharmacy College, Renigunta Road- 517520 Tirupati, Andhra Pradesh,, IN

Abstract

In recent years, plant derived polymers have evoked tremendous interest due to their diverse pharmaceutical applications such as diluents, binder, disintegrant in tablets, thickeners in oral liquids, protective colloids in suspensions, gelling agents in gels and bases in suppository. The main objective of present study was to formulate Aceclofenac oral disintegrating tablets using different natural gums and mucilage's and to study their functionality as disintegrating agents for oral disintegrating tablets. Physicochemical properties and acute toxicity studies of dried powders of isolated mucilage's were studied. Dispersible tablets of Aceclofenac were prepared by direct compression method using different natural disintegrants and Sodium Starch Glycolate. The evaluation parameters revealed that the formulated tablets had good appearance and better drug release properties. The study revealed that natural disintegrants were effective as super disintegrant.

Keywords

Aceclofenac, Disintegrant, Oral Disintegrating Tablets, Sodium Starch Glycolate.

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